Roles of plasminogen in the alterations in bone marrow hematopoietic stem cells during bone repair


We previously revealed that stromal cell-derived factor-1(SDF-1) is involved in the changes in the number of bone marrow stem cells during the bone repair process in mice. Moreover, we reported that plasminogen (Plg) deficiency delays bone repair and the accumulation of macrophages at the site of bone damage in mice. We investigated the roles of Plg in the changes in bone marrow stem cells during bone repair. We analyzed the numbers of hematopoietic stem cells(HSC) and mesenchymal stem cells (MSCs) within bone marrow from Plg-deficient and wild-type mice after a femoral bone injury using flow cytometric analysis. Plg deficiency significantly blunted a decrease in the number of HSCs after bone injury in mice, although it did not affect an increase in the number of MSCs. Plg deficiency significantly blunted the number of SDF-1- and Osterix- or SDF-1- and alkaline phosphatase-double-positive cells in the endosteum around the lesion as well as matrix metalloprotainase-9 (MMP-9) activity and mRNA levels of SDF-1 and transforming growth factor–β (TGF-β) elevated by bone injury. TGF-β signaling inhibition significantly blunted a decrease in the number of HSCs after bone injury. The present study showed that Plg is critical for the changes in bone marrow HSCs through MMP-9, TGF-β, and SDF-1 at the damaged site during bone repair in mice.




Chairman Welcome Message

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Development of science and technology is one of the most important policies mentioned by the Supreme Leader, which guarantees country's growth and prosperity.

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In the name of the creator

The 3rd National Festival and the International Congress on Stemcells andregenerative medicine is a scientific and technological event that with the trust in the Almighty Allah and with the help of scholars and experts in the field of regenerative medicine and cellular sciences will be a turning point in the country’s developments based on modern technologies. 

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